Key result
Patients undergoing chronic hemodialysis had significantly lower HDL-cholesterol levels compared to healthy subjects (41.2 vs 55.3 mg/dl in males, p<0.001), with even lower levels observed in dialysis patients with ischemic heart disease.
Why the study?
Are lower HDL-C levels associated with the presence of ischemic heart disease in patients undergoing chronic hemodialysis?
Population
36 patients undergoing maintenance hemodialysis, aged 39 to 72 years. 19 had ischemic heart disease.
Design
Cross-sectional
Authors
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Lower HDL-C and higher β/α ratios were associated with IHD in hemodialysis patients; leaves open whether targeting HDL alters outcomes.
Cross-Sectional (n=36)
No
Are lower HDL-C levels associated with the presence of ischemic heart disease in patients undergoing chronic hemodialysis?
Absolute Event Rate: 41.2% vs 55.3%
p-value: p=<0.001
Reduced serum HDL-C concentrations and increased β/αC ratios are significantly associated with the presence of ischemic heart disease in patients undergoing chronic hemodialysis.
Takahashi et al. (1980) conducted a cross-sectional in Chronic hemodialysis (n=36). Chronic hemodialysis vs. Healthy subjects was evaluated on HDL-cholesterol levels in males (mg/dl) (p=<0.001). Patients undergoing chronic hemodialysis had significantly lower HDL-cholesterol levels compared to healthy subjects (41.2 vs 55.3 mg/dl in males, p<0.001), with even lower levels observed in dialysis patients with ischemic heart disease.
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