Key result
In patients with Fabry disease, bradyarrhythmic events were associated with older age, lower resting heart rate, higher LV mass, lower LV ejection fraction, and left atrial reservoir dysfunction.
Why the study?
Are clinical and echocardiographic markers, including left atrial dysfunction, associated with bradyarrhythmic events in patients with Fabry disease?
Cross-Sectional (n=53)
Are clinical and echocardiographic markers, including left atrial dysfunction, associated with bradyarrhythmic events in patients with Fabry disease?
In patients with Fabry disease, bradyarrhythmias are common and are associated with older age, increased LV mass, reduced LVEF, and left atrial reservoir dysfunction.
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Bradyarrhythmias may indicate advanced cardiac involvement in Fabry disease; hypothesis-generating for links to left atrial dysfunction.
Di et al. (2018) conducted a cross-sectional in Fabry disease (n=53). Clinical and echocardiographic markers (including left atrial dysfunction) was evaluated on Bradyarrhythmic events (pause >2 seconds, severe bradycardia ≤40 bpm, or permanent pacemaker implantation). In patients with Fabry disease, bradyarrhythmic events were associated with older age, lower resting heart rate, higher LV mass, lower LV ejection fraction, and left atrial reservoir dysfunction.
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