Key result
Acidemia was associated with increased 30-day mortality compared to non-acidemia (28.7% vs 20.0%; HR 1.518, 95% CI 1.110-2.076, P=0.009) in patients with acute myocardial infarction.
Why the study?
Acute myocardial infarction is a leading cause of death and often combined with acidemia, but the association of acidemia with short-term mortality remained to be investigated.
Is acidemia associated with increased short-term mortality in patients with acute myocardial infarction?
Population
972 AMI patients from the MIMIC-III database
Comparison
Acidemia vs non-acidemia
Design
Retrospective propensity-score matched cohort study
Follow-up
90 days
Authors
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Acidemia may identify higher short-term mortality risk in AMI; hypothesis-generating, requires prospective validation before clinical adoption.
Cohort (n=972)
Is acidemia associated with increased short-term mortality in patients with acute myocardial infarction?
Hazard Ratio: 1.518 (95% CI 1.11–2.076)
Absolute Event Rate: 28.7% vs 20%
p-value: p=0.009
Acidemia, particularly severe acidemia (pH < 7.25), is significantly associated with higher 30-day and 90-day mortality in patients with acute myocardial infarction.
Zhang et al. (2020) conducted a cohort in Acute myocardial infarction (n=972). Acidemia vs. Non-acidemia was evaluated on 30-day mortality (HR 1.518, 95% CI 1.110-2.076, p=0.009). Acidemia was associated with increased 30-day mortality compared to non-acidemia (28.7% vs 20.0%; HR 1.518, 95% CI 1.110-2.076, P=0.009) in patients with acute myocardial infarction.
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