What question did this study set out to answer?

To investigate whether elevated expression of heat shock protein 70 (hsp70) reflects cellular stress in node-negative breast cancer and predicts clinical recurrence.

April 7, 1993JNCI Journal of the National Cancer Institute

Heat Shock Protein hsp70 in Patients With Axillary Lymph Node-Negative Breast Cancer: Prognostic Implications

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To investigate whether elevated expression of heat shock protein 70 (hsp70) reflects cellular stress in node-negative breast cancer and predicts clinical recurrence.
Measured hsp70 levels by Western blot in an exploratory cohort of primary breast tumors (N=162) to define the optimal cutpoint for disease-free survival separation.
Validated the prognostic cutpoint in an independent cohort (N=345) using univariate and multivariate survival analyses.
Correlated hsp70 expression with overall survival, disease-free survival, tumor size, age, hormone receptor status, ploidy, and flow cytometry-derived S-phase fraction.
High hsp70 expression independently predicted significantly shorter disease-free survival (P = .006), alongside S-phase fraction (P = .008) and tumor size (P = .01).
In patients receiving adjuvant therapy, hsp70 served as the sole independent predictor of cancer recurrence (P = .05).
For tumors measuring 1 to 3 cm, elevated hsp70 (P = .008) and higher S-phase fraction (P = .02) both significantly predicted disease recurrence.

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Implication

Cohort study reveals high heat shock protein 70 expression predicts shorter disease-free survival in node-negative breast cancer, suggesting its utility as a biomarker for recurrence risk.

Cite This Study

Ciocca et al. (1993) studied this question.

synapsesocial.com/papers/6a6da5b978a11c550e0811e4 https://doi.org/10.1093/jnci/85.7.570

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Implication

Cohort study reveals high heat shock protein 70 expression predicts shorter disease-free survival in node-negative breast cancer, suggesting its utility as a biomarker for recurrence risk.

Heat Shock Protein hsp70 in Patients With Axillary Lymph Node-Negative Breast Cancer: Prognostic Implications

Key Points

Discussion

Implication

Cite This Study

Heat Shock Protein hsp70 in Patients With Axillary Lymph Node-Negative Breast Cancer: Prognostic Implications

Key Points

Discussion

Implication

Cite This Study