Key result
Premenopausal women had significantly higher mean serum GH concentrations over 24 hours than men (0.78 vs 0.27 microgram/L, P<0.00005), driven by greater GH-secretory burst amplitude and mass.
Observational (n=22)
Absolute Event Rate: 0.78% vs 0.27%
p-value: p=< 0.00005
The higher mean serum GH concentrations in premenopausal women compared to men are driven by an augmentation of the GH-secretory burst mass caused by a higher burst amplitude, rather than differences in burst frequency or half-life.
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Gender differences in GH arise from higher secretory burst amplitude; leaves open mechanistic and therapeutic implications pending prospective validation.
Berg et al. (1996) conducted an observational in Gender difference in growth hormone secretion (n=22). Female gender (premenopausal women) vs. Male gender (men) was evaluated on Mean serum GH concentrations over 24 h (p=< 0.00005). Premenopausal women had significantly higher mean serum GH concentrations over 24 hours than men (0.78 vs 0.27 microgram/L, P<0.00005), driven by greater GH-secretory burst amplitude and mass.
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