What question did this study set out to answer?

To examine how age and pubertal status influence spontaneously secreted 24-hour integrated concentrations of growth hormone in normal individuals.

March 1, 1985The Journal of Clinical Endocrinology & Metabolism

The Influence of Age on the 24-Hour Integrated Concentration of Growth Hormone in Normal Individuals*

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To examine how age and pubertal status influence spontaneously secreted 24-hour integrated concentrations of growth hormone in normal individuals.
Evaluated 24-hour integrated growth hormone concentrations (IC-GH) in 173 nonobese individuals aged 7 to 65 years with heights at or above the 5th percentile.
Assessed reproducibility through repeat testing in 13 men and in 23 women evaluated during both the follicular and luteal phases of the menstrual cycle.
Analyzed IC-GH differences across age groups, sex, and pubertal development using Tanner staging.
IC-GH levels declined steadily after the second decade of life, demonstrating a significant correlation with age (r = 0.73, P < 0.0001), while displaying no significant differences between age-matched males and females.
Mean IC-GH peaked at Tanner stage 5 of puberty (7.4 ± 2.0 ng/ml), which was significantly higher than stages 2–4 (5.7 ± 1.4 ng/ml, P < 0.0005) and prepubertal baseline levels (5.8 ± 1.4 ng/ml, P < 0.001).
No significant differences in IC-GH occurred between the follicular and luteal phases in women or upon repeat testing in men.

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Implication

Cross-sectional analysis reveals declining 24-hour integrated growth hormone levels with advancing age, highlighting the need for age-specific diagnostic standards.

Cite This Study

Zadik et al. (1985) studied this question.

synapsesocial.com/papers/6a11c71d81e48c4370dcd2c3 https://doi.org/10.1210/jcem-60-3-513

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Implication

Cross-sectional analysis reveals declining 24-hour integrated growth hormone levels with advancing age, highlighting the need for age-specific diagnostic standards.

The Influence of Age on the 24-Hour Integrated Concentration of Growth Hormone in Normal Individuals*

Key Points

Discussion

Implication

Cite This Study

The Influence of Age on the 24-Hour Integrated Concentration of Growth Hormone in Normal Individuals*

Key Points

Discussion

Implication

Cite This Study

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