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September 1, 1997The Journal of Clinical Endocrinology & MetabolismOpen Access

Effect of Aging on the Sensitivity of Growth Hormone Secretion to Insulin-Like Growth Factor-I Negative Feedback*

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Implication

Reduced IGF-I suppression of GH with age in healthy volunteers; leaves open mechanisms of age-related GH decline.

Cite This Study

Chapman et al. (1997) studied this question.

synapsesocial.com/papers/6a20523b232def661be720a5 https://doi.org/10.1210/jcem.82.9.4223

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The Effects of Treatment with Recombinant Human Growth Hormone on Body Composition and Metabolism in Adults with Growth Hormone DeficiencyRCT · 1989 · 1,342 citations
2Glucose clamp technique: a method for quantifying insulin secretion and resistance.Original Research · 1979 · 7,495 citations
3Growth Hormone Replacement in Healthy Older Men Improves Body Composition but Not Functional AbilityBlinded Clinical Trial · 1996 · 483 citations
4Serum levels of the low molecular weight form of insulin-like growth factor binding protein in healthy subjects and patients with growth hormone deficiency, acromegaly and anorexia nervosaOriginal Research · 1988 · 85 citations
5A low dose euglycemic infusion of recombinant human insulin-like growth factor I rapidly suppresses fasting-enhanced pulsatile growth hormone secretion in humans.Original Research · 1993 · 195 citations