What question did this study set out to answer?

To assess how aging alters in vivo and in vitro pituitary somatotroph responsiveness to growth hormone releasing factor in male rats across their lifespan.

April 4, 2008Neuroendocrinology

Dynamics of Growth Hormone Responsiveness to Growth Hormone Releasing Factor in Aging Rats: Peripheral and Central Influences

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To assess how aging alters in vivo and in vitro pituitary somatotroph responsiveness to growth hormone releasing factor in male rats across their lifespan.
Evaluated in vivo pituitary response to 0.4 and 1.6 µg/kg rGRF(1-29) NH2 in pentobarbital-anesthetized male rats aged 2, 4, 8, 12, and 20 months.
Measured in vitro growth hormone secretion from perifused pituitary cells exposed to rGRF and somatostatin, alongside tissue hormone concentrations and plasma IGF-I.
In vivo growth hormone response to 1.6 µg/kg rGRF declined at 12 months and became completely blunted at both doses in 20-month-old rats.
Somatostatin inhibitory action on rGRF-stimulated hormone secretion varied significantly with age in vitro (p < 0.001), while pituitary somatostatin content doubled in 20-month-old rats.
Plasma insulin-like growth factor I and hypothalamic somatostatin peaked at 8 months, with plasma IGF-I reaching its lowest levels at 20 months.

Authors

NDN DeslauriersCommission Scolaire des Hautes Rivières PGPierrette GaudreauInstitut Universitaire de Gériatrie de Montréal TAThierry AbribatEli Lilly (United States)

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Implication

Experimental study reveals blunted growth hormone responsiveness to releasing factor in aging male rats, indicating progressive somatotroph dysfunction starting at twelve months of age.

Cite This Study

Deslauriers et al. (2008) studied this question.

synapsesocial.com/papers/6a85ce52518b11ca98ae9ec1 https://doi.org/10.1159/000125755

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Implication

Experimental study reveals blunted growth hormone responsiveness to releasing factor in aging male rats, indicating progressive somatotroph dysfunction starting at twelve months of age.

Dynamics of Growth Hormone Responsiveness to Growth Hormone Releasing Factor in Aging Rats: Peripheral and Central Influences

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Discussion

Implication

Cite This Study

Dynamics of Growth Hormone Responsiveness to Growth Hormone Releasing Factor in Aging Rats: Peripheral and Central Influences

Key Points

Discussion

Implication

Cite This Study

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