Population
Cultured pituitary cells of 2-day-old, 7-day-old, 15-day-old, and adult male rats
Comparison
0.01-10 microM Prostaglandin E2 and 0.01-10 nM… vs Control values (untreated cells)
Design
Preclinical
Authors
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PGE2 responsiveness rises with age in rat somatotrophs; extends developmental data but leaves open human relevance.
The sensitivity of rat pituitary somatotrophs to PGE2 increases with advancing age after birth, contrasting with the developmental pattern of sensitivity to GHRF.
Cuttler et al. (1989) studied this question.
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