Key result
Rat GH production favors males and declines with age while prolactin favors females and increases.
Population
Male and female rats at ages ranging from 14 to 120 days
Comparison
In vitro incorporation of 14C-leucine into… vs Comparison between sexes and across ages
Design
Preclinical
Authors
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Rat findings on GH/prolactin warrant no clinical change; leaves open human translational validation.
The study demonstrates that the synthesis and release of GH and prolactin in rat anterior pituitary are highly dependent on age and sex.
YAMAMOTO et al. (1970) studied this question. Age and sex was evaluated on Rates of synthesis and release of GH and prolactin. Synthesis and release of GH were generally greater in male rats and decreased after 7 weeks, whereas prolactin synthesis and release were greater in females and increased with age in both sexes.
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