Ontogenesis and Sexual Dimorphism of Rat Growth Hormone Messenger Ribonucleic Acid as Studied by in situ Hybridization

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Population

Male and female rats from foetal stage (17th day of gestation) to adulthood

Comparison

Gonadectomy performed at neonatal, prepubertal… vs Intact rats and female rats

Design

Preclinical

Authors

Discussion

Animal data show steroid-independent GH dimorphism in rats; hypothesis-generating with no bearing on human practice.

Population

Male and female rats from foetal stage (17th day of gestation) to adulthood

Intervention

Gonadectomy performed at neonatal, prepubertal, and adult periods

Comparator

Intact rats (for gonadectomy) and female rats (for sexual dimorphism)

Outcome

Growth hormone (GH) mRNA levels in the pituitarysurrogate

Sexual dimorphism of GH mRNA in rats occurs early in development and from prepuberty onwards, independent of sex steroids.

Martinoli et al. (1990) studied this question.

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