Key result
Human growth hormone greatly suppresses pituitary GHSR and GHRHR RNA expression in dwarf rats.
Why the study?
The physiological role of growth hormone secretagogue and its receptor in growth regulation is not well understood due to unknown endogenous GH secretagogue.
Does human growth hormone replacement regulate pituitary GHSR and GHRHR RNA expression in young spontaneous Dwarf rats?
Population
Twenty-five-day-old spontaneous Dwarf rats deficient in GH secretion
Comparison
Human GH injection vs control solution
Design
Preclinical experimental study
Follow-up
2 weeks
Authors
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GH feedback suppresses pituitary GHSR/GHRHR expression in GH-deficient rats; leaves open whether analogous regulation applies in humans.
Does human growth hormone replacement regulate pituitary GHSR and GHRHR RNA expression in young spontaneous Dwarf rats?
Growth hormone replacement downregulates pituitary GHSR and GHRHR RNA expression in GH-deficient dwarf rats, suggesting a feedback regulation mechanism.
Horikawa et al. (2000) studied Growth hormone deficiency. Human growth hormone vs. Control solution was evaluated on Pituitary GHSR and GHRHR RNA expression. Treatment with human growth hormone greatly suppressed the expression levels of pituitary growth hormone-secretagogue receptor and growth hormone-releasing hormone receptor RNA in both male and female spontaneous dwarf rats.
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