Key result
Growth hormone receptor mRNA is expressed in rat, rabbit, and human pituitary tissue, but functional GH receptors were not demonstrated on pituitary membranes by radioligand binding studies.
Population
Rat, rabbit, and human pituitary glands
Design
Preclinical
Authors
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May question direct GH feedback on pituitary; leaves open functional receptor confirmation beyond mRNA detection.
The study demonstrates that while the growth hormone receptor gene is expressed in pituitary tissue, functional receptors may not be inserted into the plasma membranes.
Fräser et al. (1991) studied this question. Growth hormone receptor gene expression analysis was evaluated on Presence of GH receptor mRNA and functional GH receptors. Growth hormone receptor mRNA is expressed in rat, rabbit, and human pituitary tissue, but functional GH receptors were not demonstrated on pituitary membranes by radioligand binding studies.
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