Key result
In spontaneous dwarf rats, GH mRNA levels were severely reduced (2.6-6.0% of normal) without gross deletion or rearrangement of the GH gene, suggesting it as a model for isolated GH deficiency.
Authors
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Provides a rodent model for isolated GH deficiency; leaves open translation to human GH regulation.
Nogami et al. (1989) studied Pituitary dwarfism. Spontaneous dwarf rat (SDR) phenotype vs. Normal control rats was evaluated on GH and PRL gene expression in the pituitary gland. In spontaneous dwarf rats, GH mRNA levels were severely reduced (2.6-6.0% of normal) without gross deletion or rearrangement of the GH gene, suggesting it as a model for isolated GH deficiency.
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