Key result
Pygmy mice exhibit subnormal pituitary GH and PRL and fail to respond to PRL administration.
Why the study?
The pg mutation's effects on the synthesis, release, and function of growth hormone and prolactin in pygmy mice were not fully understood.
The pg mutation in mice induces multifaceted changes affecting the synthesis, release, and function of growth hormone and prolactin.
Pygmy mouse GH/PRL defects should not change practice; leaves open mechanistic research on pg mutation effects.
Basal levels of GH and PRL in the serum and pituitary gland of normal (Pg/ Pg) and pygmy (pg/pg) (VY X C3H) F-l hybrid mice were measured by homologous radioimmunoassays. The serum concentrations of GH and PRL in pygmy mice at approximately 90 days of age were found to be no different from those in corresponding normal controls. The pituitary concentrations of the two hormones, however, were substantially subnormal in pygmy mice. Perphena-zine injection failed to stimulate PRL release by pygmy (pg/pg) pituitaries, in contrast to the marked increase in serum PRL levels of the normal Pg/Pg mice. Daily administration of 100 μg of ovine PRL for 8 weeks produced none or very little increase in the body weight of pygmy mice. These results suggest that the pg mutation induces a multifaceted change affecting the synthesis, release, and function of growth hormone and prolactin.
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Sinha et al. (1979) studied Pygmy mutation. pg mutation vs. Normal controls (Pg/Pg) was evaluated on Serum and pituitary concentrations of GH and PRL. Pygmy mice exhibited normal serum but subnormal pituitary concentrations of GH and PRL, and failed to release PRL upon perphenazine injection or gain weight with ovine PRL administration.
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