January 1, 1990Endocrinology

Molecular Mechanism of Growth Hormone (GH) Deficiency in the Spontaneous Dwarf Rat: Detection of Abnormal Splicing of GH Messenger Ribonucleic Acid by the Polymerase Chain Reaction*

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Population

Spontaneous dwarf rat (SDR) experimental model for pituitary dwarfism (primary cultures from SDR pituitaries)

Design

Preclinical

Authors

Discussion

Validates spontaneous dwarf rat as precise GH deficiency model; leaves open translation to human disorders or therapies.

Population

Spontaneous dwarf rat (SDR) experimental model for pituitary dwarfism (primary cultures from SDR pituitaries)

Intervention

GH-releasing factor and (Bu)2cAMP

Outcome

Accumulation and secretion of GH, amount of GH mRNA, and GH gene sequence/splicingsurrogate

This study identifies the specific genetic point mutation responsible for growth hormone deficiency in the spontaneous dwarf rat model.

Takeuchi et al. (1990) studied this question.

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