Key result
Dwarf rats exhibited significantly lower pituitary GH content compared to normal rats (2.9 vs 140 μg, P<0.001) and released smaller amounts of GH in response to GRF.
Population
Mutant GH-deficient dwarf rats and normal rats of the same strain, including adult females and 20- to…
Comparison
Intravenous injections of GH-releasing factor… vs Normal AS rats or baseline measurements.
Design
Preclinical
Authors
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Supports dwarf rat model of early GH deficiency; leaves open translation to human pituitary disorders.
Absolute Event Rate: 2.9% vs 140%
p-value: p=<0.001
Dwarf rats exhibit GH deficiency as early as 20 days of age and have reduced GH release in response to GRF due to markedly reduced pituitary GH stores.
Carmignac et al. (1990) studied Growth hormone deficiency. GH-releasing factor (GRF) vs. Normal AS rats was evaluated on Pituitary GH content (μg) (p=<0.001). Dwarf rats exhibited significantly lower pituitary GH content compared to normal rats (2.9 vs 140 μg, P<0.001) and released smaller amounts of GH in response to GRF.
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