Key result
Recombinant human GH produces a marked sustained rise in IGF-I levels in GH-deficient dwarf rats.
Population
Male GH-deficient dwarf (dw/dw) rats
Comparison
Recombinant human GH daily injections from 28 to… vs Saline vehicle daily injections
Design
Preclinical
Follow-up
42 days (from 28 to 70 days of age)
Authors
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Does not support changes in clinical GH use; extends evidence for direct GH regulation of IGF-I during maturation independent of sex steroids.
p-value: p=< 0.0001
In GH-deficient dwarf rats, GH administration induces a marked rise in IGF-I levels during sexual maturation without affecting sex steroid levels.
Crawford et al. (1994) studied GH deficiency. Recombinant human GH vs. Saline vehicle was evaluated on IGF-I levels during sexual maturation (p=< 0.0001). Treatment with recombinant human GH produced a marked sustained rise in IGF-I levels in male GH-deficient dwarf rats compared to untreated rats (P < 0.0001).
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