May 1, 1994Endocrinology

Administration of growth hormone (GH), but not insulin-like growth factor-I (IGF-I), by continuous infusion can induce the formation of the 150-kilodalton IGF-binding protein-3 complex in GH-deficient rats

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Population

GH-deficient (GHD) rat model

Comparison

Growth hormone by either twice daily injections… vs Normal littermates and comparison between…

Design

Preclinical

Follow-up

7 days

Authors

SGSharron GargoskyTiGenix (Spain)

Discussion

Member takes

Implication

Rodent data caution against clinical extrapolation; extend mechanistic understanding of GH delivery on IGFBP-3 complexes.

Structured PICO

Population

GH-deficient (GHD) rat model

Intervention

Growth hormone (GH) by either twice daily injections (1 mg/kg) or continuous infusion (2.4 mg/kg.day) or IGF-I by continuous infusion (1.4 mg/kg.day) for 7 days

Comparator

Normal littermates and comparison between different treatment regimens

Outcome

Formation of the 150-kilodalton IGF-binding protein-3 (IGFBP-3) complexsurrogate

Continuous infusion of growth hormone, but not IGF-I or intermittent GH, induces the formation of the 150-kDa IGFBP-3 ternary complex in GH-deficient rats.

Cite This Study

Sharron Gargosky (1994) studied this question.

synapsesocial.com/papers/6a952a523d7e4fca39b2d5c6 https://doi.org/10.1210/en.134.5.2267

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Administration of growth hormone (GH), but not insulin-like growth factor-I (IGF-I), by continuous infusion can induce the formation of the 150-kilodalton IGF-binding protein-3 complex in GH-deficient rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Administration of growth hormone (GH), but not insulin-like growth factor-I (IGF-I), by continuous infusion can induce the formation of the 150-kilodalton IGF-binding protein-3 complex in GH-deficient rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider