Why the study?
What are the pharmacokinetics of rhIGF-I in adults with growth hormone deficiency compared to normal individuals?
Population
9 adults with growth hormone deficiency (GHD), mean age 25 +/- 3 yr
Comparison
recombinant human insulin-like growth factor I… vs Normal individuals studied similarly
Design
Other
Follow-up
24 hours
Authors
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May influence rhIGF-I dosing in GHD; hypothesis-generating for efficacy and safety outcomes.
What are the pharmacokinetics of rhIGF-I in adults with growth hormone deficiency compared to normal individuals?
In adults with growth hormone deficiency, rhIGF-I has normal absorption and distribution but faster elimination kinetics, with bioavailability modulated by binding proteins.
Mauras et al. (1999) studied this question.
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