Population
Profoundly GH-deficient dwarf rats, moderately GH-deficient Tgr rats, GH receptor-binding protein-null mice…
Comparison
GH treatment, neonatal MSG treatment, or… vs Wild-type rats, untreated dw/dw rats
Design
Preclinical
Authors
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May inform GH-leptin-adiposity mechanisms in deficiency states; leaves open human translation and clinical relevance.
Severe GH deficiency in dw/dw rats is accompanied by paradoxical leanness and hypoleptinemia, suggesting disruption of preadipocyte differentiation or proliferation.
Davies et al. (2007) studied this question.
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