Key result
Low-dose GH administration for 14 days increased insulin sensitivity (P<0.01) and suppressed endogenous peak GH release (P<0.01) in young healthy adults.
Why the study?
Does low-dose growth hormone administration improve insulin sensitivity in young healthy adults?
Population
12 young healthy adults (7 males, age 19-29 years)
Comparison
Low-dose growth hormone 1.7 microg/kg.d for 14… vs Placebo for 14 days (cross-over design)
Design
RCT, double-blind
Follow-up
14 days per treatment block
Authors
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Low-dose GH may enhance insulin sensitivity in healthy adults; extends short-term RCT data and leaves open translation to metabolic disease.
RCT (n=12)
Double-blind
Does low-dose growth hormone administration improve insulin sensitivity in young healthy adults?
p-value: p=<0.01
Low-dose growth hormone administration enhances insulin sensitivity and suppresses endogenous peak GH release in young healthy adults, likely mediated by increased free IGF-I.
Yuen et al. (2004) conducted an RCT in Healthy (n=12). Growth Hormone (GH) vs. Placebo was evaluated on Insulin sensitivity (S(I)) (p=<0.01). Low-dose GH administration for 14 days increased insulin sensitivity (P<0.01) and suppressed endogenous peak GH release (P<0.01) in young healthy adults.
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