November 1, 2000The Journal of Clinical Endocrinology & MetabolismOpen Access

The Effect of Four Weeks of Supraphysiological Growth Hormone Administration on the Insulin-Like Growth Factor Axis in Women and Men¹

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Why the study?

Does exogenous growth hormone administration increase serum insulin-like growth factor I (IGF-I) and related markers in healthy adults?

Structured PICO

Does exogenous growth hormone administration increase serum insulin-like growth factor I (IGF-I) and related markers in healthy adults?

Population

99 healthy subjects (49 women and 50 men; mean +/- SE age, 25.6+/-0.6 (women)/25.7+/-0.6 yr (men))

Intervention

Growth hormone 0.1 IU/kg x day (n = 30) or 0.2 IU/kg x day (n = 29) for 4 weeks

Comparator

Placebo (n = 40) for 4 weeks

Outcome

Serum insulin-like growth factor I (IGF-I) and related markers (ALS, IGFBP-3, IGFBP-2) levels over 12 weeks (4 weeks treatment, 8 weeks follow-up)surrogate

Exogenous growth hormone administration elicits a more robust increase in IGF-I in men compared to women, making IGF-I the most specific marker for detecting supraphysiological GH exposure.

Discussion

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Implication

Sex-specific IGF-I monitoring is warranted during GH therapy; extends validation of IGF-I as the primary marker for supraphysiological exposure.

Cite This Study

Dall et al. (2000) studied this question.

synapsesocial.com/papers/6a20878f27dc97a0e8cd456b https://doi.org/10.1210/jcem.85.11.6964

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Implication

Sex-specific IGF-I monitoring is warranted during GH therapy; extends validation of IGF-I as the primary marker for supraphysiological exposure.

The Effect of Four Weeks of Supraphysiological Growth Hormone Administration on the Insulin-Like Growth Factor Axis in Women and Men¹

Structured PICO

Discussion

Implication

Cite This Study

The Effect of Four Weeks of Supraphysiological Growth Hormone Administration on the Insulin-Like Growth Factor Axis in Women and Men¹

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider