Why the study?
Does growth hormone replacement therapy improve IGF-I levels, body composition, and quality of life in adults with GH deficiency?
Population
665 adults with GH deficiency (332 women; 169 childhood-onset GHD; mean age, 44 yr)
Design
Cohort
Follow-up
12 months
Authors
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Supports sex-specific GH dosing in deficiency; hypothesis-generating for differential responses pending randomized confirmation.
Does growth hormone replacement therapy improve IGF-I levels, body composition, and quality of life in adults with GH deficiency?
Growth hormone replacement therapy in adults with GH deficiency improves IGF-I levels, body composition, and quality of life, though women may require higher replacement doses than men.
Bengtsson et al. (1999) studied this question.
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