What question did this study set out to answer?

Assess the therapeutic effects of growth hormone replacement on body composition, physical performance, quality of life, and lipid profiles in adults with adult-onset growth hormone deficiency.

May 1, 2004The Journal of Clinical Endocrinology & MetabolismOpen Access

Growth Hormone (GH) Replacement Therapy in Adult-Onset GH Deficiency: Effects on Body Composition in Men and Women in a Double-Blind, Randomized, Placebo-Controlled Trial

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Why the study?

Does growth hormone replacement therapy improve body composition, strength, endurance, and quality of life in subjects with adult-onset GH deficiency?

Key Points

Assess the therapeutic effects of growth hormone replacement on body composition, physical performance, quality of life, and lipid profiles in adults with adult-onset growth hormone deficiency.
Randomized, double-blind, placebo-controlled, multicenter trial involving 166 adults with adult-onset growth hormone deficiency evaluated over a 12-month period.
Growth hormone was initiated at 0.0125 mg/kg/d and adjusted (0.00625 to 0.025 mg/kg/d) based on patient tolerance, leaving 79% on 0.0125 mg/kg/d and 21% on 0.00625 mg/kg/d at 12 months.
Growth hormone replacement significantly decreased total body fat and trunk fat while increasing lean body mass compared with baseline in both men and women.
Serum total cholesterol and low-density lipoprotein improved significantly (P < 0.05 for all), with men showing larger increases in IGF-I standard deviation scores than women at similar doses.
No significant treatment effects were observed for physical strength, endurance, quality of life, or bone mineral density over 12 months.

Structured PICO

Does growth hormone replacement therapy improve body composition, strength, endurance, and quality of life in subjects with adult-onset GH deficiency?

Population

166 subjects with adult-onset GH deficiency (AGHD)

Intervention

Growth hormone (GH) initiated at 0.0125 mg/kg.d, increased to 0.025 mg/kg.d as tolerated, or decreased to 0.00625 mg/kg.d for 12 months

Comparator

Placebo

Outcome

Body composition, strength and endurance, and quality of lifesurrogate

In adults with GH deficiency, 12 months of GH replacement improves body composition and lipid profiles but does not significantly alter strength, endurance, or quality of life.

Discussion

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Implication

Supports GH replacement for body composition and lipids in adult GH deficiency; challenges expectations of broad gains in strength or quality of life.

Cite This Study

Hoffman et al. (2004) studied this question.

synapsesocial.com/papers/6a81961aa19bfff313b955c2 https://doi.org/10.1210/jc.2003-030346

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Implication

Supports GH replacement for body composition and lipids in adult GH deficiency; challenges expectations of broad gains in strength or quality of life.

Growth Hormone (GH) Replacement Therapy in Adult-Onset GH Deficiency: Effects on Body Composition in Men and Women in a Double-Blind, Randomized, Placebo-Controlled Trial

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Growth Hormone (GH) Replacement Therapy in Adult-Onset GH Deficiency: Effects on Body Composition in Men and Women in a Double-Blind, Randomized, Placebo-Controlled Trial

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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