What question did this study set out to answer?

Investigate the role of annexin II and p36 in the process of catecholamine secretion in chromaffin cells.

Annexin II in exocytosis: catecholamine secretion requires the translocation of p36 to the subplasmalemmal region in chromaffin cells.

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Randomized trial shows translocation of p36 is crucial for catecholamine secretion in chromaffin cells, indicating its role in exocytosis.

Investigate the role of annexin II and p36 in the process of catecholamine secretion in chromaffin cells.
Performed quantitative confocal immunofluorescence and immunoprecipitation analyses.
Microinjected a synthetic peptide into chromaffin cells to study its effects on exocytosis.
Observed the translocation of p36 in response to nicotinic stimulation.
Translocation of p36 to subplasmalemmal regions following stimulation was documented.
Peptide microinjection completely inhibited nicotine-induced recruitment of p36 and exocytosis.
Loss of Ca2+ was found essential for p36 translocation and triggering exocytosis.

Chasserot‐Golaz et al. (1996) studied this question.

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Randomized trial shows translocation of p36 is crucial for catecholamine secretion in chromaffin cells, indicating its role in exocytosis.