Key result
The abstract describes the methodology for measuring adenosine and S-AMP levels during isoproterenol infusion in rabbits, but results are not provided.
May support adenosine's role in coronary flow-metabolism coupling; leaves open translation to human physiology.
Objective: Adenosine, derived from hydrolysis of 5'-AMP, may be involved in coupling coronary blood flow to cardiac function and metabolism. The purpose of this study was to measure interstitial fluid (ISF) adenosine and S-AMP levels, and cytosolic S-AMP in in situ rabbit heart during P-adrenergic stimulation. Methods: Isoproterenol was infused into open chest rabbits (n = 7) at 1 and 4 pg. kg-' .min-'.
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Headrick et al. (1996) studied this question. Isoproterenol was evaluated on interstitial fluid (ISF) adenosine and S-AMP levels, and cytosolic S-AMP. The abstract describes the methodology for measuring adenosine and S-AMP levels during isoproterenol infusion in rabbits, but results are not provided.
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