February 1, 1988Canadian Journal of Physiology and Pharmacology

Contribution of adenosine to changes in coronary flow in metabolically stimulated rat heart

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Population

Crystalloid-perfused, isovolumic rat hearts

Comparison

Adenosine deaminase or the adenosine receptor… vs Stimulation with norepinephrine or isoproterenol…

Design

Preclinical

Authors

RWRoger J. WillisGriffith University

Discussion

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Implication

Supports adenosine's role in rat coronary vasodilation; leaves open translation to human physiology or therapy.

Structured PICO

Population

Crystalloid-perfused, isovolumic rat hearts

Intervention

Adenosine deaminase (2 U.mL-1) or the adenosine receptor antagonist 8-phenyltheophylline (5 x 10(-6) M) added to the perfusate during stimulation with norepinephrine (1 x 10(-7) M) or isoproterenol (5 x 10(-8) M)

Comparator

Stimulation with norepinephrine or isoproterenol alone without adenosine deaminase or 8-phenyltheophylline

Outcome

Changes in coronary flow and left ventricular developed pressure (LVDP)surrogate

Approximately one-third of the coronary vasodilation resulting from metabolic stimulation by catecholamines in the rat heart is mediated by extracellular adenosine.

Cite This Study

Roger J. Willis (1988) studied this question.

synapsesocial.com/papers/6a903efe0691efebbb2785ad https://doi.org/10.1139/y88-030

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Contribution of adenosine to changes in coronary flow in metabolically stimulated rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Contribution of adenosine to changes in coronary flow in metabolically stimulated rat heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider