Key result
Intracoronary adenosine deaminase prevented the increase in coronary perfusate flow and significantly blunted the increase in myocardial oxygen consumption induced by catecholamines.
Why the study?
Does endogenous adenosine participate in catecholamine-induced global coronary functional hyperemia in isolated guinea pig hearts?
Population
Isolated, perfused guinea pig hearts
Comparison
Intracoronary adenosine deaminase during… vs Intracoronary infusions of norepinephrine and…
Design
Preclinical
Authors
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Endogenous adenosine mediates catecholamine-induced coronary hyperemia in guinea pig hearts; leaves open translation to human physiology or practice.
Does endogenous adenosine participate in catecholamine-induced global coronary functional hyperemia in isolated guinea pig hearts?
Endogenous adenosine plays an important role in catecholamine-induced global coronary functional hyperemia in isolated guinea pig hearts.
Kang et al. (1990) studied this question. Intracoronary adenosine deaminase (ADA) vs. Absence of ADA was evaluated on Coronary perfusate flow (CPF) and myocardial oxygen consumption (MVO2). Intracoronary adenosine deaminase prevented the increase in coronary perfusate flow and significantly blunted the increase in myocardial oxygen consumption induced by catecholamines.
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