Why the study?
Does endogenous adenosine inhibit catecholamine-elicited contractile responses in oxygenated rat hearts?
Population
Perfused oxygenated rat hearts
Comparison
Perfusion with adenosine deaminase prior… vs Isoproterenol stimulation alone
Design
Preclinical
Authors
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Endogenous adenosine may limit beta-adrenergic contractility in oxygenated myocardium; leaves open relevance to human heart disease or therapy.
Does endogenous adenosine inhibit catecholamine-elicited contractile responses in oxygenated rat hearts?
Endogenous adenosine serves as an important negative feedback modulator that prevents full mechanical responsiveness to beta-adrenoceptor stimulation in the oxygenated myocardium.
Dobson et al. (1986) studied this question.
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