Key result
Adenosine at 1 µM reduced the isoproterenol-induced increase in cyclic AMP concentration and phosphorylase activity in oxygenated rat ventricular myocardium by 35% and 75%, respectively.
Population
Slices of rat ventricular myocardium 0.5 mm thick weighing 15-20 mg
Comparison
Adenosine (1 µM) added to isoproterenol (10 µM) vs Isoproterenol (10 µM) alone
Design
Preclinical
Authors
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Hypothesis-generating for adenosine's anti-adrenergic effects in myocardium; leaves open clinical relevance pending human studies.
Adenosine attenuates catecholamine-induced increases in cyclic AMP and phosphorylase activity in oxygenated rat myocardium, suggesting it may antagonize catecholamine-elicited glycogenolysis.
J G Dobson (1978) studied this question. Adenosine vs. Isoproterenol alone was evaluated on Increase in cyclic AMP concentration and phosphorylase activity. Adenosine at 1 µM reduced the isoproterenol-induced increase in cyclic AMP concentration and phosphorylase activity in oxygenated rat ventricular myocardium by 35% and 75%, respectively.
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