Key result
Adenosine decreased isoproterenol-elicited increases in myocardial protein phosphorylation by 50-86% and reduced contractile responses in isolated rat hearts.
Adenosine attenuates and calcium augments catecholamine-induced myocardial protein phosphorylation, suggesting they modulate adrenergic metabolic and contractile responses.
No takes yet. Share an insight, caveat, or question.
Should not change clinical management of catecholamine effects; leaves open translation of rat-heart phosphorylation findings to humans.
Fenton et al. (1984) studied this question. Adenosine and Calcium vs. Isoproterenol alone / baseline was evaluated on 32P incorporation into proteins (myocardial protein phosphorylation) and contractile responses. Adenosine decreased isoproterenol-elicited increases in myocardial protein phosphorylation by 50-86% and reduced contractile responses in isolated rat hearts.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: