An Interactive Strategy for the Assembly of Complex, Branched Oligosaccharide Domains on a Solid Support: A Concise Synthesis of the Lewisb Domain in Bioconjugatable Form

Minimal use of protecting groups is required in the synthesis of the branched hexa-saccharide Lewisb 1. Thus, donor and acceptor glycosyl units were linked stereo-selectively to the polymer-bound glycal in such a way that an oligosaccharide recognition element is formed which can be bound to a carrier protein.