Key result
Anticoagulant and/or antithrombotic therapy was associated with a significantly higher ABC score sum in patients with gastrointestinal bleeding, but did not significantly affect mortality rates.
Why the study?
The study was conducted to examine the effect of anticoagulant and/or antithrombotic drug administration on gastrointestinal bleeding severity and mortality.
Does anticoagulant and/or antithrombotic therapy affect gastrointestinal bleeding severity and mortality in patients hospitalized with manifest GI bleeding?
Cross-Sectional (n=216)
No
Does anticoagulant and/or antithrombotic therapy affect gastrointestinal bleeding severity and mortality in patients hospitalized with manifest GI bleeding?
Absolute Event Rate: 19.6% vs 13.1%
p-value: p=0.335
In patients hospitalized with gastrointestinal bleeding, prior use of anticoagulant or antithrombotic therapy is associated with higher bleeding severity scores but not increased mortality.
Prior anticoagulant/antithrombotic use may flag higher bleeding severity in GI bleed admissions; leaves open effects on mortality and management.
Background:The main aim of this study was to examine the effect of anticoagulant and/or antithrombic drug administration on gastrointestinal (GI) bleeding severity and the mortality rate.Methods: This study included 217 patients hospitalized at the Clinic of Internal Medicine at the University Clinical Hospital Mostar during the period from January 1, 2019, to December 31, 2021, with a diagnosis of manifest GI bleeding and anemia of unknown cause where an endoscopy revealed bleeding in the GI system.Data were collected from the hospital information system based on age, blood tests, and comorbidities (ABC) score parameters and were scored.The patients were divided into two groups, with one undergoing anticoagulant and/or antithrombotic therapy and the other not receiving these therapies, and the ABC score values were compared.Main findings: The total share of patients receiving anticoagulant and/or antithrombotic therapy was only 25.93%, which is statistically significantly less than the share of patients without treatment.Disorders of consciousness were statistically significantly more common in patients undergoing anticoagulant and/or antithrombotic therapy than in those without treatment (p=0.001).The subjects with therapy also achieved a significantly higher ABC sum than those without (p=0.001),while there was no statistically significant difference in the mortality rate between the two groups (p=0.335).Principal conclusions: Patients using anticoagulant and/or antithrombic therapy achieved a statistically significantly higher ABC score sum compared to those not receiving such therapy.However, no significant differences in mortality rates were found between the two groups of patients.
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Bencun et al. (2023) conducted a cross-sectional in Gastrointestinal bleeding (n=216). Anticoagulant and/or antithrombotic therapy vs. No anticoagulant and/or antithrombotic therapy was evaluated on Mortality rate (p=0.335). Anticoagulant and/or antithrombotic therapy was associated with a significantly higher ABC score sum in patients with gastrointestinal bleeding, but did not significantly affect mortality rates.
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