Key result
Several natural compounds have been reported to suppress cytotoxic drug-induced cardiac injury through regulation of the PI3K/Akt signaling pathway.
Why the study?
Cardiotoxicity is a critical concern with cytotoxic drugs, where dysregulation of the PI3K/Akt pathway contributes to cardiac damage, prompting a review of protective natural compounds.
Do natural compounds protect against cytotoxic drug-induced cardiotoxicity through regulation of the PI3K/Akt signaling pathway?
Do natural compounds protect against cytotoxic drug-induced cardiotoxicity through regulation of the PI3K/Akt signaling pathway?
Natural compounds may offer a protective strategy against cytotoxic drug-induced cardiotoxicity by modulating the PI3K/Akt signaling pathway.
May inform adjunctive strategies against chemotherapy cardiotoxicity; hypothesis-generating and requires rigorous clinical trials.
Cardiotoxicity is a critical concern in the use of several cytotoxic drugs. Induction of apoptosis, inflammation, and autophagy following dysregulation of the PI3K/Akt signaling pathway contributes to the cardiac damage induced by these drugs. Several natural compounds (NCs), including ferulic acid, gingerol, salvianolic acid B, paeonol, apigenin, calycosin, rutin, neferine, higenamine, vincristine, micheliolide, astragaloside IV, and astragalus polysaccharide, have been reported to suppress cytotoxic drug-induced cardiac injury. This article reviews these NCs that have been reported to have a protective effect against cytotoxic drug-induced cardiotoxicity through regulation of the PI3K/Akt signaling pathway.
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Yarmohammadi et al. (2020) conducted a review in Cytotoxic drug-induced cardiotoxicity. Natural compounds was evaluated on Cardiac injury. Several natural compounds have been reported to suppress cytotoxic drug-induced cardiac injury through regulation of the PI3K/Akt signaling pathway.
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