Key result
Natural products like curcumin and resveratrol protect against chemotherapy-induced cardiotoxicity in preclinical models.
Why the study?
The protective effects of natural products against chemotherapy-induced cardiotoxicity have been investigated but require comprehensive synthesis.
Do natural products protect against chemotherapy-induced cardiotoxicity?
Do natural products protect against chemotherapy-induced cardiotoxicity?
Answers are grounded in this paper and cite their sources.
This review summarizes the potential of ten specific natural products to protect against chemotherapy-induced cardiotoxicity.
To complete this review, relevant literatures were searched from several scientific databases including Google, Google Scholar, Scopus, Web of Science and Pubmed.The categories of keywords used for searching are "Natural Products" or "Phytoconstituents" or "Isolated Compounds" or "Natural Compounds" or "Curcumin" or "Mangiferin" or "Naringenin" or "Quercetin" or "6-Gingerol" or "Lycopene" or "Resveratrol" or "Apigenin" or "Proanthocyanidins" or "Indole-3carbinol" and "Cardioprotection" or "Anticancer" or "Chemotherapy" or "Cardiotoxicity" or "Cardiotonic".After screening of literatures from 2005 to 2019, a total of ten natural products investigated the protective effect against chemotherapy-induced cardiotoxicity and that were included in the present review.
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Othman et al. (2020) conducted a review in Chemotherapy-induced cardiotoxicity. Natural products (e.g., curcumin, mangiferin, resveratrol) vs. Chemotherapy alone was evaluated. Ten natural products, including curcumin, mangiferin, and resveratrol, demonstrate significant cardioprotective effects against chemotherapy-induced cardiotoxicity in preclinical models.
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