Key result
Both Kv1.5 and Kv2.1 contribute to mouse atrial IK,s, and Kv2.1 contributes to mouse atrial Iss, demonstrating two molecularly distinct components of the repolarizing current.
Population
Atrial myocytes isolated from adult and postnatal day 15 C57BL6 mice, and transgenic mice expressing a…
Comparison
Pharmacological blockade, antisense… vs Non-transgenic or untreated atrial cells
Design
Preclinical
Authors
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Distinguishes Kv channel roles in mouse atrial repolarization; leaves open translation to human arrhythmias or therapies.
This study identifies the specific molecular correlates (Kv1.5 and Kv2.1) responsible for distinct components of repolarizing voltage-gated potassium currents in mouse atrial myocytes.
Bou‐Abboud et al. (2000) studied this question. Kv1.5 or Kv2.1 antisense oligodeoxynucleotides and Kv2.1N216Flag mutation vs. Non-transgenic or unexposed atrial cells was evaluated on Outward K+ current densities (IK,s and Iss). Both Kv1.5 and Kv2.1 contribute to mouse atrial IK,s, and Kv2.1 contributes to mouse atrial Iss, demonstrating two molecularly distinct components of the repolarizing current.
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