Key result
Targeted disruption of the Kv1.4 gene did not eliminate the transient outward current in adult murine ventricular myocytes, demonstrating that Kv1.4 is not its molecular basis.
Absolute Event Rate: 44.4% vs 53.8%
p-value: p=<0.02
Kv1.4 is not the molecular basis of the transient outward current (Ito) in adult murine ventricular myocytes, as its targeted disruption does not alter the inactivating portion of the current.
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Challenges prior attribution of murine Ito to Kv1.4; leaves open the channel's molecular identity and human translational relevance.
London et al. (1998) studied this question. Kv1.4 gene knockout vs. Wild-type (Kv1.4+/+) was evaluated on Peak current densities at 60 mV (pA pF-1) (p=<0.02). Targeted disruption of the Kv1.4 gene did not eliminate the transient outward current in adult murine ventricular myocytes, demonstrating that Kv1.4 is not its molecular basis.
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