What question did this study set out to answer?

To develop a mild and chemoselective catalytic system for the oxidative lactonization of diols using an amino alcohol-derived iridium complex.

June 12, 2002Organic Letters

Mild and Chemoselective Synthesis of Lactones from Diols Using a Novel Metal−Ligand Bifunctional Catalyst

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Authors

TSTakeyuki SuzukiSanken Electric (Japan)KMKenji MoritaWaseda University MTMika TsuchidaNagano Municipal Hospital

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Implication

Experimental study demonstrates efficient oxidative lactonization of diols using an iridium catalyst, suggesting a practical route for mild room-temperature synthesis.

Key Points

To develop a mild and chemoselective catalytic system for the oxidative lactonization of diols using an amino alcohol-derived iridium complex.
Synthesized and characterized the catalyst precursor Cp*IrCl[OCH2C(C6H5)2NH2] using single-crystal X-ray analysis.
Conducted catalytic oxidative lactonization of 1,4- and 1,5-diols in acetone or butanone at substrate-to-catalyst molar ratios ranging from 200 to 1000.
The bifunctional iridium catalyst afforded high yields of lactones at room temperature.
The catalytic protocol exhibited broad functional group tolerance across tested diol substrates.

Cite This Study

Suzuki et al. (2002) studied this question.

synapsesocial.com/papers/6a6dd63d8031ec7bb1db6a7d https://doi.org/10.1021/ol026091h

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Implication

Experimental study demonstrates efficient oxidative lactonization of diols using an iridium catalyst, suggesting a practical route for mild room-temperature synthesis.

Mild and Chemoselective Synthesis of Lactones from Diols Using a Novel Metal−Ligand Bifunctional Catalyst

Discussion

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Implication

Key Points

Cite This Study

Mild and Chemoselective Synthesis of Lactones from Diols Using a Novel Metal−Ligand Bifunctional Catalyst

Discussion

Member takes

Implication

Key Points

Cite This Study

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