Nickel‐Catalyzed Dehydrogenative Couplings

In last decade, nickel‐catalyzed organic reactions made tremendous progress due to their distinctive redox character. It has unfolded many contemporary synthetic transformations namely cross‐coupling, carbon‐carbon bond cleavage and directed C−H functionalization to achieve the targeted medicinal organic molecules in a straightforward manner. Beyond these well documented approaches, dehydrogenative coupling a challenging bond forming strategy by expelling hydrogen from unfunctionalized coupling partners is less explored. In accord with this, nickel‐catalyst has been studied to perform different class of dehydrogenative coupling between easily accessible substrates. Nickel catalyzed processes for the construction of carbon‐carbon, carbon‐heteroatom and heteroatom‐heteroatom bonds by dehydrogenation are discussed herein in a sustainable manner.