Key result
PPAR-gamma agonists exhibit a wide spectrum of effects that may be beneficial for treating cardiovascular conditions such as atherosclerosis, hypertension, and aortic aneurysm.
Why the study?
Do PPAR-gamma agonists provide therapeutic benefits for cardiovascular disorders such as atherosclerosis?
Do PPAR-gamma agonists provide therapeutic benefits for cardiovascular disorders such as atherosclerosis?
PPAR-gamma agonists, currently used for diabetes, show potential for broader clinical application in treating cardiovascular conditions like atherosclerosis due to their pleiotropic effects on inflammation and lipid metabolism.
PPAR agonists show cardiovascular therapeutic potential; leaves open clinical adoption pending randomized evidence.
Peroxisome proliferation-activated receptors (PPARs) are ligand-activated transcription factors that mainly regulate genes responsible for fatty acid (FA) and energy metabolism. There are three members of the PPAR family, PPAR-α, PPAR- β/δ and PPAR-γ. All three isoforms have therapeutic potential for treatment of cardiovascular disorders, and PPAR agonists are currently being actively studied in pre-clinical and clinical trials. PPAR γ agonists, main tissue expressing isoform, have potential to influence on inflammation processes, reduce oxidative stress, improve endothelial function and plays an important role in lipid metabolism. PPAR-γ agonists are used as insulin sensitizers for treatment of diabetes; however, there is accumulating evidence that their clinical application can be broadened. The wide spectrum of PPAR-γ activation effects may be beneficial for treatment of various cardiovascular conditions as atherosclerosis, hypertension and aortic aneurysm, including surgical interventions. In this Review we will discuss the implication of PPAR-γ in the cardiovascular system and potential role of PPAR-γ agonists in treatment of conditions associated with high cardiovascular risks.
No takes yet. Share an insight, caveat, or question.
Ivanova et al. (2017) conducted a review in Cardiovascular disorders. PPAR-gamma agonists was evaluated. PPAR-gamma agonists exhibit a wide spectrum of effects that may be beneficial for treating cardiovascular conditions such as atherosclerosis, hypertension, and aortic aneurysm.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: