The autogenous bone graft, still the golden standard in oral and maxillofacial surgery, needs a second side surgery. As an alternative, bone morphogenetic proteins (BMP-2 and BMP-7) have been searched in pre-clinical and clinical studies, specifically in sinus augmentation. A comparison of the aforementioned studies revealed very different results, also due to variations in study model. The available data on use of rhBMP-2 and 7 are promising in showing an osteoinductive potential in sinus augmentation, but not conclusive in the predictability and consistency results to allow clinical use in this stage, other than in well designed clinical trials.
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Zijderveld et al. (2002) studied this question.
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