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Heparin-Induced Persistent Hyperthermia and Hyponatremia in a Patient With Open Fracture — A Diagnostic Dilemma

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Case report reveals heparin's role in inducing fever and hyponatremia post-operatively, highlighting implications.

Patient experienced fever and hyponatremia after heparin administration following an open tibia fracture, indicating a drug-induced reaction.
Upon discontinuation of heparin, the patient’s hyperthermia resolved, and serum sodium levels normalized, emphasizing the medication's potential side effects.
Clinical evaluation ruled out other common causes of fever and hyponatremia, reinforcing the diagnosis of heparin-induced reactions.
Raising awareness about rare adverse effects of heparin may aid clinicians in better management of patients receiving anticoagulation therapy.

Nair et al. (2025) studied this question.

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