Key result
Abnormal arterial stiffness after AMI is linked to ~4-point lower peak VO2 before discharge.
Why the study?
The relationship between arterial stiffness and oxygen uptake in patients with acute myocardial infarction remained unclear.
Observational (n=101)
No
In patients with acute myocardial infarction, increased arterial stiffness measured by the cardio-ankle vascular index (CAVI) is independently associated with reduced peak oxygen uptake, highlighting the role of vascular stiffness in limiting exercise tolerance.
Abnormal arterial stiffness may identify AMI patients with impaired exercise capacity; leaves open whether stiffness modification improves peak VO2.
The relationship between arterial stiffness and oxygen uptake (VO2) in patients with acute myocardial infarction (AMI) remains unclear. We aimed to investigate this relationship and factors contributing to VO2 in patients with AMI. The role of arterial stiffness in cardio–skeletal muscle coupling during exercise was then elucidated. Upon discharge, we measured exercise capacity using cardiopulmonary exercise testing (CPX), assessed arterial stiffness with the cardio–ankle vascular index (CAVI), and determined body composition to assess the skeletal muscle mass of 101 patients with AMI. Patients were categorized based on their CAVI scores into three groups: (i) normal (CAVI: ≤7.9), (ii) borderline (CAVI: 8.0–8.9), and (iii) abnormal (CAVI: ≥9.0). Subsequently, VO2 was compared among these groups. The relationship between the CAVI and VO2 Peak during CPX and factors contributing to VO2 Peak were investigated. The abnormal CAVI group had a significantly lower VO2 Peak than the normal and borderline groups. The CAVI was associated with VO2 Peak. Furthermore, the CAVI was found to be a factor contributing to VO2 Peak. These findings suggest that arterial stiffness in tissue blood distribution and blood supply causes systemic exercise limits in patients with AMI. This suggests that arterial stiffness plays a significant role in cardio–vascular–skeletal muscle coupling.
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Ogawa et al. (2023) conducted an observational in Acute Myocardial Infarction (n=101). Abnormal arterial stiffness (CAVI ≥ 9.0) vs. Normal or borderline arterial stiffness (CAVI < 9.0) was evaluated on Peak oxygen uptake (VO2 Peak) measured by cardiopulmonary exercise testing. Patients with acute myocardial infarction and abnormal arterial stiffness (CAVI ≥ 9.0) had a significantly lower peak oxygen uptake compared to those with normal or borderline arterial stiffness.
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