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January 1, 2001Japanese Circulation Journal-english EditionOpen Access

Short-Term Physical Training Improves Ventilatory Response to Exercise After Coronary Arterial Bypass Surgery.

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Key result

Short-term physical training for 2 weeks after coronary arterial bypass grafting significantly decreased the V•E–V•CO2 slope from 38.9 to 35.1 (p<0.05) and increased peak cardiac output.

Why the study?

Does short-term physical training improve ventilatory response and cardiac output during exercise in patients after CABG?

Population

57 patients 2 weeks post-coronary arterial bypass grafting for old myocardial infarction and/or angina…

Comparison

Short-term physical training for 2 weeks. vs Sedentary convalescence for 2 weeks.

Design

RCT, Randomly assigned according to the ward to which they were admitted

Follow-up

2 weeks

Authors

HAHitoshi AdachiGunma Prefectural Cardiovascular CenterHIHaruki ItohSakakibara HospitalSSShigeki SakuraiGunma University

Discussion

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Implication

Hypothesis-generating for early post-CABG training; larger randomized trials needed before practice change.

Study Design

Type

RCT (n=57)

Blinding

Open-label

Randomization

Quasi-randomized according to the ward to which patients were admitted

Multicenter

No

Structured PICO

Does short-term physical training improve ventilatory response and cardiac output during exercise in patients after CABG?

P
Population
57 post-CABG patients (mean age 62, 19% female) with underlying myocardial infarction or angina pectoris, assigned to 2 weeks of physical training or sedentary convalescence.
I
Intervention
Short-term physical training (exercise training using treadmill or cycle ergometer twice a day for 30 minutes per session at an intensity equivalent to the ventilatory anaerobic threshold) for 2 weeks.
C
Comparator
Sedentary convalescence for 2 weeks.
O
Outcome
Ventilatory response (VE-VCO2 slope) and cardiac output during cardiopulmonary exercise testing.surrogate

Main Result

Absolute Event Rate: 35.1% vs 41.5%

p-value: p=<0.05

Short-term physical training initiated two weeks after CABG significantly improves exercise hyperpnea and increases cardiac output during exercise.

Limitations

  • Patients had an almost normal ejection fraction, so results may not apply to CABG patients with deteriorated cardiac function.
  • Quasi-randomization based on admitted ward rather than true randomization.
  • Small sample size.
  • Patients had an almost normal ejection fraction, so results cannot be adopted to CABG patients with deteriorated cardiac function.

Cite This Study

Adachi et al. (2001) conducted an RCT in Post-Coronary Arterial Bypass Grafting (CABG) (n=57). Short-term physical training vs. Sedentary convalescence was evaluated on Minute ventilation-carbon dioxide output (V•E–V•CO2) slope (p=<0.05). Short-term physical training for 2 weeks after coronary arterial bypass grafting significantly decreased the V•E–V•CO2 slope from 38.9 to 35.1 (p<0.05) and increased peak cardiac output.

synapsesocial.com/papers/6a6e0440ac440176ef275ac3https://doi.org/10.1253/jcj.65.419
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effect of Physical Training on Skeletal Muscle in Patients with Chronic Heart Failure2000 · 69 citations
  2. 2Oxygen utilization and ventilation during exercise in patients with chronic cardiac failure.1982 · 920 citations
  3. 3Time Course of Recovery During Cardiac Rehabilitation1995 · 44 citations
  4. 4Controlled trial of physical training in chronic heart failure. Exercise performance, hemodynamics, ventilation, and autonomic function.1992 · 954 citations
  5. 5Therapeutic Effects of Physical Training in Coronary Heart Disease2008 · 14 citations