Key result
Schizophrenia is associated with a standardized mortality rate of about 2.5, leading to a 15 to 20 year reduction in life expectancy, largely driven by cardiovascular disease.
Population
Individuals with schizophrenia
Design
Review
Authors
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Schizophrenia patients warrant routine CVD risk screening; confirms excess mortality and extends calls for integrated care trials.
Effect estimate: SMR ~2.5
Schizophrenia is associated with a 15-20 year reduction in life expectancy, largely driven by cardiovascular mortality exacerbated by lifestyle factors, metabolic syndrome, and antipsychotic medications.
Ringen et al. (2014) conducted a review in Schizophrenia. Schizophrenia vs. General population was evaluated on Cardiovascular disease mortality (SMR ~2.5). Schizophrenia is associated with a standardized mortality rate of about 2.5, leading to a 15 to 20 year reduction in life expectancy, largely driven by cardiovascular disease.
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