Mp05-02 pi-Rads 4 and 5 Lesions Are the Risk Factors for Biochemical Recurrence in the Low-Intermediate Risk Prostate Cancer

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You have accessJournal of UrologyProstate Cancer: Detection & Screening I (MP05)1 Sep 2021MP05-02 PI-RADS 4 AND 5 LESIONS ARE THE RISK FACTORS FOR BIOCHEMICAL RECURRENCE IN THE LOW-INTERMEDIATE RISK PROSTATE CANCER Kyung Hwan Kim, Byeong Jin Kang, Si Kyun Park, Gwon Kyeong Lee, Ja Yoon Ku, and Hong Koo Ha Kyung Hwan KimKyung Hwan Kim More articles by this author , Byeong Jin KangByeong Jin Kang More articles by this author , Si Kyun ParkSi Kyun Park More articles by this author , Gwon Kyeong LeeGwon Kyeong Lee More articles by this author , Ja Yoon KuJa Yoon Ku More articles by this author , and Hong Koo HaHong Koo Ha More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001972.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The clinical value of multiparametric magnetic resonance imaging (mpMRI) combined with Prostate Imaging Reporting and Data System (PI-RADS) version 2 for detecting and screening prostate cancer in preoperative setting has been well demonstrated. The aim of this study was to investigate the relationship between PI-RADS 4-5 lesions on multiparametric MRI (mpMRI) and biochemical recurrence (BCR) after prostatectomy in the low-intermediate risk prostate cancer patients. METHODS: Out of 231 prostate cancer patients who underwent mpMRI scan and radical prostatectomy in our institute from Aug, 2016 to Feb, 2019, we identified 174 cases with low-intermediate risk. Patients with Gleason score ≤ 7 and prostate specific antigen (PSA) ≤ 20 ng/ml were classified as low-intermediate risk prostate cancer group. BCR was defined as PSA ≥ 0.2 ng/ml with a second confirmatory laboratory value. Cox proportional hazard analysis and Kaplan-Meier analysis were performed. RESULTS: BCR developed in 29 (16.7%) patients at a median follow-up of 28.0 months. Median of age, PSA and PSA density (PSAD) were 66.5 years, 7.3 ng/ml and 0.20 ng/ml2, respectively. PI-RADS 1-2, 3, 4 and 5 index lesions were observed in 11 (6.3%), 44 (25.3), 69 (39.7%) and 50 (28.7%) patients, respectively. In Cox proportional hazard model, PI-RADS 4-5 lesions were significant risk factors for BCR (p = 0.045) along with PSAD and seminal vesicle invasion. BCR free survival rate was significantly lower in PI-RADS ≥ 4 group than PI-RADS ≤ 3 group (log rank p value = 0.08). Mean time to BCR in PI-RADS ≥ 4 and PI-RADS ≤ 3 patients were 36.5 and 41.1 months, respectively. CONCLUSIONS: PI-RADS 4 and 5 lesions on preoperative mpMRI were identified as significant predictors for BCR in the low-intermediate risk prostate cancer patients. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e76-e77 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kyung Hwan Kim More articles by this author Byeong Jin Kang More articles by this author Si Kyun Park More articles by this author Gwon Kyeong Lee More articles by this author Ja Yoon Ku More articles by this author Hong Koo Ha More articles by this author Expand All Advertisement Loading ...