What question did this study set out to answer?

To review the structure, distribution, and signaling cascades of adiponectin receptors in the central nervous system and explore their involvement in brain disorders.

June 30, 2011British Journal of PharmacologyOpen Access

Adiponectin receptor signalling in the brain

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To review the structure, distribution, and signaling cascades of adiponectin receptors in the central nervous system and explore their involvement in brain disorders.
Synthesized molecular evidence on adiponectin receptor subtypes (AdipoR1, AdipoR2, T-cadherin) and associated downstream pathways (AMPK, p38-MAPK, PPARα, NF-κB).
Evaluated preclinical studies detailing receptor expression in cortical neurons, endothelial cells, the hypothalamus, brainstem, and pituitary.
Adiponectin receptors are widely distributed throughout key brain areas, including the cortex, hypothalamus, brainstem, and cerebral vasculature.
Receptor activation engages multiple metabolic and inflammatory signaling pathways, though specific mechanisms in neuropathology remain sparsely investigated.
Modulation of adiponectin receptor pathways represents an emerging therapeutic strategy for brain diseases.

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Implication

Narrative review outlines adiponectin receptor expression and signaling pathways across the brain, highlighting therapeutic opportunities for neurological disorders.

Cite This Study

Thundyil et al. (2011) studied this question.

synapsesocial.com/papers/6a6e0d3435aa2c282ce01c50 https://doi.org/10.1111/j.1476-5381.2011.01560.x

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Implication

Narrative review outlines adiponectin receptor expression and signaling pathways across the brain, highlighting therapeutic opportunities for neurological disorders.

Adiponectin receptor signalling in the brain

Key Points

Discussion

Implication

Cite This Study

Adiponectin receptor signalling in the brain

Key Points

Discussion

Implication

Cite This Study

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