Key result
Protein kinase A phosphorylation of α1C Ser1700 does not have a major role in the sympathetic stimulation of Ca2+ current and contraction in the adult murine heart.
Population
Transgenic mice enabling selective and inducible expression of FLAG-epitope-tagged…
Design
Preclinical
Authors
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Clarifies PKA targets on CaV1.2; leaves open clinical translation to inotropy or arrhythmias.
Protein kinase A phosphorylation of α1C Ser(1700) is not required for sympathetic stimulation of Ca2+ current and contraction in the adult murine heart, challenging previous postulates.
Yang et al. (2013) studied this question. Transgenic expression of mutant CaV1.2 channels was evaluated on Adrenergic regulation of CaV1.2 current and fractional shortening of cardiomyocytes. Protein kinase A phosphorylation of α1C Ser1700 does not have a major role in the sympathetic stimulation of Ca2+ current and contraction in the adult murine heart.
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