Key result
Stimulation of cultured adult feline ventricular myocytes to contract with isoproterenol induced the emergence of extensive vinculin-positive focal adhesions and intercellular junctions.
Mechanical forces from contractile activity regulate vinculin distribution and myofibrillar order in cultured adult feline heart cells.
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No clinical implications yet; leaves open in vivo relevance of beta-adrenergic effects on myocyte junctions.
Simpson et al. (1993) studied Cultured adult feline ventricular myocytes. Isoproterenol (beta-adrenergic agonist) / contractile activity vs. Quiescent myocytes was evaluated on Myofibrillar organization and vinculin distribution. Stimulation of cultured adult feline ventricular myocytes to contract with isoproterenol induced the emergence of extensive vinculin-positive focal adhesions and intercellular junctions.
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